The Z-Number Enigma: A Study through an Experiment

Bayesian perspective over time

Thomas Bayes, the founder of Bayesian vision, entered the University of Edinburgh in 1719 to study logic and theology. Returning in 1722, he worked with his father in a small church. He also was a mathematician and in 1740 he made a novel discovery which he never published, but his friend Richard Price found it in his notes after his death in 1761, reedited it and published it. But until L...

The Luteal Phase after GnRHa Trigger-Understanding An Enigma

Teaching 4th Graders Concepts Related to Sustainable Development: An Experiment

In order to show that some of the shortcomings of current 4th grade curriculum in meeting contemporary needs of the society, especially in regard to sustainable development, can be met via teaching, a short course consisting of deliberations on key concepts in sustainable development was designed and carried out on a sample of 58 students of both genders. The pre- and post-test comparisons reve...

Alp/Enigma Family Proteins Cooperate in Z-Disc Formation and Myofibril Assembly

The Drosophila Alp/Enigma family protein Zasp52 localizes to myotendinous junctions and Z-discs. It is required for terminal muscle differentiation and muscle attachment. Its vertebrate ortholog ZASP/Cypher also localizes to Z-discs, interacts with α-actinin through its PDZ domain, and is involved in Z-disc maintenance. Human mutations in ZASP cause myopathies and cardiomyopathies. Here we show...

Loss of enigma homolog protein results in dilated cardiomyopathy.

RATIONALE The Z-line, alternatively termed the Z-band or Z-disc, is a highly ordered structure at the border between 2 sarcomeres. Enigma subfamily proteins (Enigma, Enigma homolog protein, and Cypher) of the PDZ-LIM domain protein family are Z-line proteins. Among the Enigma subfamily, Cypher has been demonstrated to play a pivotal role in the structure and function of striated muscle, whereas...